Association of three single nucleotide polymorphisms of interleukin -35 for detection and prediction of women with breast cancer in Erbil city

Abstract

Background: Interleukins have a substantial role in the improvement of many types of cancer. Interleukin genes have many single nucleotide polymorphisms (SNPs) that may alter protein synthesis or function, and many of them have been related to cancer risk. The objective of this study is to determine whether particular SNPs in interleukin 35 contributed to breast cancer susceptibility and severity. Methods: For IL-35 interleukin SNP detection, seventy benign breast disease, BC patients, 70 malignant BC and control healthy donors were obtained from patient’s sera. We utilized an allelic discrimination approach that could genotype a large number of samples quickly. The long-term consequences and clinico-pathological aspects were also investigated. Results: study is focused on three distinct IL-35 SNPs (IL12 G/A, IL12 ACT, and EBI3) and revealed a substantial upsurge in the chance of developing malignant breast cancer exclusively when compared to the control group. Both benign and malignant patients had significantly lower blood levels of IL-35 than controls (p< 0.05). Regardless of your age or BMI, there are a few things to consider (BMI) on the level of serum IL-35. Conclusion: Polymorphisms in the interior of key interleukin genes (IL12 ACT, IL12 G/A & EBI3) seem to play a substantial complete role in breast cancer vulnerability or strictness.

Keywords

• breast cancer
• interleukin 35
• single nucleotide gene polymorphism