International Journal of Extreme Manufacturing (Jan 2023)

Engineering vascularized organotypic tissues via module assembly

  • Zhenzhen Zhou,
  • Changru Liu,
  • Yuting Guo,
  • Yuan Pang,
  • Wei Sun

DOI
https://doi.org/10.1088/2631-7990/acfcf2
Journal volume & issue
Vol. 6, no. 1
p. 012006

Abstract

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Adequate vascularization is a critical determinant for the successful construction and clinical implementation of complex organotypic tissue models. Currently, low cell and vessel density and insufficient vascular maturation make vascularized organotypic tissue construction difficult, greatly limiting its use in tissue engineering and regenerative medicine. To address these limitations, recent studies have adopted pre-vascularized microtissue assembly for the rapid generation of functional tissue analogs with dense vascular networks and high cell density. In this article, we summarize the development of module assembly-based vascularized organotypic tissue construction and its application in tissue repair and regeneration, organ-scale tissue biomanufacturing, as well as advanced tissue modeling.

Keywords