Phenotypic and Genotypic Adaptations in Pseudomonas aeruginosa Biofilms following Long-Term Exposure to an Alginate Oligomer Therapy

Juliette L. Oakley; Rebecca Weiser; Lydia C. Powell; Julian Forton; Eshwar Mahenthiralingam; Philip D. Rye; Katja E. Hill; David W. Thomas; Manon F. Pritchard

doi:10.1128/mSphere.01216-20

mSphere (Feb 2021)

Phenotypic and Genotypic Adaptations in Pseudomonas aeruginosa Biofilms following Long-Term Exposure to an Alginate Oligomer Therapy

Juliette L. Oakley,
Rebecca Weiser,
Lydia C. Powell,
Julian Forton,
Eshwar Mahenthiralingam,
Philip D. Rye,
Katja E. Hill,
David W. Thomas,
Manon F. Pritchard

Affiliations

Juliette L. Oakley: Advanced Therapies Group, Oral and Biomedical Sciences, School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, United Kingdom
Rebecca Weiser: Cardiff School of Bioscience, Cardiff University, Cardiff, United Kingdom
Lydia C. Powell: Advanced Therapies Group, Oral and Biomedical Sciences, School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, United Kingdom
Julian Forton: Department of Paediatric Respiratory Medicine/Cystic Fibrosis Unit, Children’s Hospital for Wales, Cardiff, United Kingdom
Eshwar Mahenthiralingam: ORCiD; Cardiff School of Bioscience, Cardiff University, Cardiff, United Kingdom
Philip D. Rye: AlgiPharma AS, Sandvika, Norway
Katja E. Hill: ORCiD; Advanced Therapies Group, Oral and Biomedical Sciences, School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, United Kingdom
David W. Thomas: Advanced Therapies Group, Oral and Biomedical Sciences, School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, United Kingdom
Manon F. Pritchard: ORCiD; Advanced Therapies Group, Oral and Biomedical Sciences, School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, United Kingdom

DOI: https://doi.org/10.1128/mSphere.01216-20
Journal volume & issue: Vol. 6, no. 1

Abstract

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The emergence of multidrug-resistant (MDR) pathogens within biofilms in the cystic fibrosis lung results in increased morbidity. An inhalation therapy derived from alginate, OligoG CF-5/20, is currently in clinical trials for cystic fibrosis patients.

Published in mSphere

ISSN: 2379-5042 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msphere

About the journal