Nature Communications (Feb 2023)
Genomic and immune landscape Of metastatic pheochromocytoma and paraganglioma
- Bruna Calsina,
- Elena Piñeiro-Yáñez,
- Ángel M. Martínez-Montes,
- Eduardo Caleiras,
- Ángel Fernández-Sanromán,
- María Monteagudo,
- Rafael Torres-Pérez,
- Coral Fustero-Torre,
- Marta Pulgarín-Alfaro,
- Eduardo Gil,
- Rocío Letón,
- Scherezade Jiménez,
- Santiago García-Martín,
- Maria Carmen Martin,
- Juan María Roldán-Romero,
- Javier Lanillos,
- Sara Mellid,
- María Santos,
- Alberto Díaz-Talavera,
- Ángeles Rubio,
- Patricia González,
- Barbara Hernando,
- Nicole Bechmann,
- Margo Dona,
- María Calatayud,
- Sonsoles Guadalix,
- Cristina Álvarez-Escolá,
- Rita M. Regojo,
- Javier Aller,
- Maria Isabel Del Olmo-Garcia,
- Adrià López-Fernández,
- Stephanie M. J. Fliedner,
- Elena Rapizzi,
- Martin Fassnacht,
- Felix Beuschlein,
- Marcus Quinkler,
- Rodrigo A. Toledo,
- Massimo Mannelli,
- Henri J. Timmers,
- Graeme Eisenhofer,
- Sandra Rodríguez-Perales,
- Orlando Domínguez,
- Geoffrey Macintyre,
- Maria Currás-Freixes,
- Cristina Rodríguez-Antona,
- Alberto Cascón,
- Luis J. Leandro-García,
- Cristina Montero-Conde,
- Giovanna Roncador,
- Juan Fernando García-García,
- Karel Pacak,
- Fátima Al-Shahrour,
- Mercedes Robledo
Affiliations
- Bruna Calsina
- Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO)
- Elena Piñeiro-Yáñez
- Bioinformatics Unit, Structural Biology Program, Spanish National Cancer Research Centre (CNIO)
- Ángel M. Martínez-Montes
- Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO)
- Eduardo Caleiras
- Histopathology Core Unit, Biotechnology Program, Spanish National Cancer Research Centre (CNIO)
- Ángel Fernández-Sanromán
- Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO)
- María Monteagudo
- Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO)
- Rafael Torres-Pérez
- Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO)
- Coral Fustero-Torre
- Bioinformatics Unit, Structural Biology Program, Spanish National Cancer Research Centre (CNIO)
- Marta Pulgarín-Alfaro
- Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO)
- Eduardo Gil
- Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO)
- Rocío Letón
- Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO)
- Scherezade Jiménez
- Monoclonal Antibodies Core Unit, Biotechnology Program, Spanish National Cancer Research Centre (CNIO)
- Santiago García-Martín
- Bioinformatics Unit, Structural Biology Program, Spanish National Cancer Research Centre (CNIO)
- Maria Carmen Martin
- Molecular Cytogenetics and Genome Engineering Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO)
- Juan María Roldán-Romero
- Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO)
- Javier Lanillos
- Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO)
- Sara Mellid
- Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO)
- María Santos
- Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO)
- Alberto Díaz-Talavera
- Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO)
- Ángeles Rubio
- Genomics Core Unit, Biotechnology Program, Spanish National Cancer Research Centre (CNIO)
- Patricia González
- Histopathology Core Unit, Biotechnology Program, Spanish National Cancer Research Centre (CNIO)
- Barbara Hernando
- Computational Oncology Group, Structural Biology Program, Spanish National Cancer Research Centre (CNIO)
- Nicole Bechmann
- Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden
- Margo Dona
- Department of Internal Medicine, Radboud University Medical Centre
- María Calatayud
- Department of Endocrinology, 12 de Octubre University Hospital
- Sonsoles Guadalix
- Department of Endocrinology, 12 de Octubre University Hospital
- Cristina Álvarez-Escolá
- Department of Endocrinology, La Paz University Hospital
- Rita M. Regojo
- Department of Pathology, La Paz University Hospital
- Javier Aller
- Department of Endocrinology, Puerta de Hierro University Hospital
- Maria Isabel Del Olmo-Garcia
- Department of Endocrinology and Nutrition, University Hospital La Fe
- Adrià López-Fernández
- Department of Medical Oncology, Vall d’Hebrón Hospital
- Stephanie M. J. Fliedner
- Neuroendocrine Oncology and Metabolism, Medical Department I, Center of Brain, Behavior, and Metabolism, University Medical Center Schleswig-Holstein Lübeck
- Elena Rapizzi
- Department of Experimental and Clinical Biomedical Sciences, University of Florence
- Martin Fassnacht
- Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital Würzburg, University of Würzburg
- Felix Beuschlein
- Medizinische Klinik und Poliklinik IV, Klinikum der Universität München
- Marcus Quinkler
- Endocrinology in Charlottenburg Stuttgarter Platz 1
- Rodrigo A. Toledo
- Gastrointestinal and Endocrine Tumors, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron Barcelona Hospital Campus
- Massimo Mannelli
- Department of Experimental and Clinical Biomedical Sciences, University of Florence
- Henri J. Timmers
- Department of Internal Medicine, Radboud University Medical Centre
- Graeme Eisenhofer
- Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden
- Sandra Rodríguez-Perales
- Molecular Cytogenetics and Genome Engineering Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO)
- Orlando Domínguez
- Genomics Core Unit, Biotechnology Program, Spanish National Cancer Research Centre (CNIO)
- Geoffrey Macintyre
- Computational Oncology Group, Structural Biology Program, Spanish National Cancer Research Centre (CNIO)
- Maria Currás-Freixes
- Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO)
- Cristina Rodríguez-Antona
- Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO)
- Alberto Cascón
- Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO)
- Luis J. Leandro-García
- Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO)
- Cristina Montero-Conde
- Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO)
- Giovanna Roncador
- Monoclonal Antibodies Core Unit, Biotechnology Program, Spanish National Cancer Research Centre (CNIO)
- Juan Fernando García-García
- Department of Pathology, MD Anderson Cancer Center
- Karel Pacak
- Section of Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health
- Fátima Al-Shahrour
- Bioinformatics Unit, Structural Biology Program, Spanish National Cancer Research Centre (CNIO)
- Mercedes Robledo
- Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO)
- DOI
- https://doi.org/10.1038/s41467-023-36769-6
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 20
Abstract
The molecular mechanisms underlying metastasis in pheochromocytoma/paraganglioma (mPPGL) remain to be explored. Here, the authors perform genomic and immunogenomic profiling of mPPGL tumors and suggest potential biomarkers for risk of metastasis and immunotherapy response.
