The miR-200 family: multiple effects on gliomas

Abstract

Lilei Peng,1 Jie Fu,2 Yang Ming1 1Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, People’s Republic of China; 2Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, People’s Republic of China Abstract: Gliomas are the most common type of primary brain tumors. MicroRNAs (miRNAs) are small noncoding RNAs that can epigenetically regulate target gene expression. The microRNA 200 family includes miR-200a, 200b, 200c, 141 and 429. Numerous studies have indicated that members of the miR-200 family play an important role in glioma development and metastasis. In this review, we summarize the data from various studies and highlight the effects of miR-200 on glioma metastasis, therapeutic response and prognosis. Keywords: glioma, miR-200 family, metastasis, chemoresistance, radioresistance

Keywords

• glioma
• miR-200 family
• metastasis
• chemoresistance
• radioresistance