GOLGA7 rs11337, a Polymorphism at the MicroRNA Binding Site, Is Associated with Glioma Prognosis

Linghui Zhou; Shanshan Dong; Yujiao Deng; Pengtao Yang; Yi Zheng; Li Yao; Ming Zhang; Si Yang; Ying Wu; Zhen Zhai; Na Li; Huafeng Kang; Zhijun Dai

doi:10.1016/j.omtn.2019.08.006

Molecular Therapy: Nucleic Acids (Dec 2019)

GOLGA7 rs11337, a Polymorphism at the MicroRNA Binding Site, Is Associated with Glioma Prognosis

Linghui Zhou,
Shanshan Dong,
Yujiao Deng,
Pengtao Yang,
Yi Zheng,
Li Yao,
Ming Zhang,
Si Yang,
Ying Wu,
Zhen Zhai,
Na Li,
Huafeng Kang,
Zhijun Dai

Affiliations

Linghui Zhou: Department of Breast Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China
Shanshan Dong: School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China
Yujiao Deng: Department of Breast Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China
Pengtao Yang: Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China
Yi Zheng: Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China
Li Yao: Department of Neurology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China
Ming Zhang: Department of Neurosurgery, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China
Si Yang: Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China
Ying Wu: Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China
Zhen Zhai: Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China
Na Li: Department of Breast Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China
Huafeng Kang: Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China; Corresponding author: Huafeng Kang, Department of Oncology, The 2nd Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China.
Zhijun Dai: Department of Breast Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China; Corresponding author: Zhijun Dai, Department of Breast Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

DOI: https://doi.org/10.1016/j.omtn.2019.08.006
Journal volume & issue: Vol. 18
pp. 56 – 65

Abstract

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MicroRNAs bind to the 3′ untranslated regions of mRNAs, affecting translation, tumorigenesis, and apoptosis. This study evaluated the role of TYMS (rs1059394, C > T, and rs2847153, G > A), RYR3 (rs1044129, G > A), KIAA0423 (rs1053667, T > C), and GOLGA7 (rs11337, G > T) polymorphisms for assessment of glioma risk and prognosis among the Chinese Han population. Five single-nucleotide polymorphisms were assessed in 605 glioma patients and 1,300 controls. We found a significant correlation between rs1059394 and glioma susceptibility in the homozygote and dominant genetic models (TT versus CC, odds ratio [OR] = 0.71, 95% confidence interval [CI] = 0.52–0.97, p = 0.03; CT+TT versus CC, OR = 0.74, 95% CI = 0.55–0.99, p = 0.04). The results of the Kaplan-Meier and log rank tests revealed that the rs11337 GG genotype correlated with better overall survival of glioma patients (p = 0.017) than the GT genotype. Multivariate Cox regression analysis results also showed that the rs11337 GT genotype correlated with worse overall survival (p = 0.017, hazard ratio [HR] = 1.25, 95% CI = 1.04–1.5) than the GG genotype. These results suggest that GOLGA7 (rs11337) polymorphism may play a role in the prognosis of glioma patients and that TYMS (rs1059394) is associated with glioma risk. Keywords: GOLGA7, rs11337, polymorphism, cancer risk, prognosis, microRNA-binding site

Published in Molecular Therapy: Nucleic Acids

ISSN: 2162-2531 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.cell.com/molecular-therapy-family/nucleic-acids/latest-content

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