Nature Communications (Jul 2018)
Reactive astrocytic S1P3 signaling modulates the blood–tumor barrier in brain metastases
- Brunilde Gril,
- Anurag N. Paranjape,
- Stephan Woditschka,
- Emily Hua,
- Emma L. Dolan,
- Jeffrey Hanson,
- Xiaolin Wu,
- Wojciech Kloc,
- Ewa Izycka-Swieszewska,
- Renata Duchnowska,
- Rafał Pęksa,
- Wojciech Biernat,
- Jacek Jassem,
- Naema Nayyar,
- Priscilla K. Brastianos,
- O. Morgan Hall,
- Cody J. Peer,
- William D. Figg,
- Gary T. Pauly,
- Christina Robinson,
- Simone Difilippantonio,
- Emilie Bialecki,
- Philippe Metellus,
- Joel P. Schneider,
- Patricia S. Steeg
Affiliations
- Brunilde Gril
- Women’s Malignancies Branch, CCR, NCI
- Anurag N. Paranjape
- Women’s Malignancies Branch, CCR, NCI
- Stephan Woditschka
- Women’s Malignancies Branch, CCR, NCI
- Emily Hua
- Women’s Malignancies Branch, CCR, NCI
- Emma L. Dolan
- Women’s Malignancies Branch, CCR, NCI
- Jeffrey Hanson
- Laboratory of Pathology, CCR, NCI
- Xiaolin Wu
- Genomics Laboratory, Frederick National Laboratory for Cancer Research
- Wojciech Kloc
- Department of Neurology & Neurosurgery, Varmia & Masuria University
- Ewa Izycka-Swieszewska
- Department of Pathology & Neuropathology, Medical University of Gdańsk
- Renata Duchnowska
- Department of Oncology, Military Institute of Medicine
- Rafał Pęksa
- Department of Pathology, Medical University of Gdańsk
- Wojciech Biernat
- Department of Pathology, Medical University of Gdańsk
- Jacek Jassem
- Department of Oncology and Radiotherapy, Medical University of Gdańsk
- Naema Nayyar
- Division of Neuro-Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School
- Priscilla K. Brastianos
- Division of Neuro-Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School
- O. Morgan Hall
- Genitourinary Malignancies Branch, CCR, NCI
- Cody J. Peer
- Genitourinary Malignancies Branch, CCR, NCI
- William D. Figg
- Genitourinary Malignancies Branch, CCR, NCI
- Gary T. Pauly
- Chemical Biology Laboratory, CCR, NCI
- Christina Robinson
- Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research
- Simone Difilippantonio
- Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research
- Emilie Bialecki
- Département de Neurochirurgie, Hôpital Privé Clairval, Ramsay Général de Santé
- Philippe Metellus
- Département de Neurochirurgie, Hôpital Privé Clairval, Ramsay Général de Santé
- Joel P. Schneider
- Chemical Biology Laboratory, CCR, NCI
- Patricia S. Steeg
- Women’s Malignancies Branch, CCR, NCI
- DOI
- https://doi.org/10.1038/s41467-018-05030-w
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 18
Abstract
When brain metastases form, the blood–brain barrier morphs into the blood–tumor barrier (BTB), surrounded by neuroinflammatory response. Here, the authors show that S1P3 is upregulated in neuroinflammatory response in highly BTB permeable lesions, and modulation of S1P3 could impact BTB permeability.
