Effect of miR-27b on the proliferation and apoptosis of diffuse large b-cell lymphoma cells by targeting the regulation of MET/PI3K/AKT pathway

Abstract

Highlights 1. MET is a direct target of miR-27b. 2. Low expression of miR-27b is correlated with the growth activity of DLBCL cells. 3. miR-27b inhibits the proliferation and invasiveness of DLBCL cells, and promotes the apoptosis of the cells by targeting MET and inhibiting the activity of the MET/PI3K/AKT pathway.

Keywords

• Diffuse large B-cell lymphoma
• miR-27b
• PI3K
• AKT pathway
• Apoptosis