Nature Communications (Mar 2016)
Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation
Abstract
The proteasome plays a key role in proteostasis by mediating the degradation of ubiquitinated substrates. Here the authors show that an open-gate mutant of the proteasome is hyperactive towards a subset of substrates and can effectively delay the accumulation of toxic protein aggregates.