Nature Communications (Mar 2016)

Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation

  • Won Hoon Choi,
  • Stefanie A. H. de Poot,
  • Jung Hoon Lee,
  • Ji Hyeon Kim,
  • Dong Hoon Han,
  • Yun Kyung Kim,
  • Daniel Finley,
  • Min Jae Lee

DOI
https://doi.org/10.1038/ncomms10963
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 12

Abstract

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The proteasome plays a key role in proteostasis by mediating the degradation of ubiquitinated substrates. Here the authors show that an open-gate mutant of the proteasome is hyperactive towards a subset of substrates and can effectively delay the accumulation of toxic protein aggregates.