The Serum IL-6 Profile and Treg/Th17 Peripheral Cell Populations in Patients with Type 1 Diabetes

Monika Ryba-Stanisławowska; Maria Skrzypkowska; Jolanta Myśliwska; Małgorzata Myśliwiec

doi:10.1155/2013/205284

Mediators of Inflammation (Jan 2013)

The Serum IL-6 Profile and Treg/Th17 Peripheral Cell Populations in Patients with Type 1 Diabetes

Monika Ryba-Stanisławowska,
Maria Skrzypkowska,
Jolanta Myśliwska,
Małgorzata Myśliwiec

Affiliations

Monika Ryba-Stanisławowska: Department of Immunology, Medical University of Gdańsk, Dębinki 1, 80-210 Gdańsk, Poland
Maria Skrzypkowska: Department of Immunology, Medical University of Gdańsk, Dębinki 1, 80-210 Gdańsk, Poland
Jolanta Myśliwska: Department of Immunology, Medical University of Gdańsk, Dębinki 1, 80-210 Gdańsk, Poland
Małgorzata Myśliwiec: Clinic of Pediatrics, Department of Diabetology and Endocrinology, Medical University of Gdańsk, 80-210 Gdańsk, Poland

DOI: https://doi.org/10.1155/2013/205284
Journal volume & issue: Vol. 2013

Abstract

Read online

IL-6 is a pleiotropic cytokine involved in the regulation of the immune response, inflammation, and hematopoeisis. Its elevated levels are found in a range of autoimmune and chronic inflammatory diseases. IL-6 is also involved in regulation of the balance between two T cell subsets: Tregs and Th17, which have contradictory functions in the control of inflammation. The present study provides a quantitative analysis regarding the Th17/Treg cell balance in peripheral blood of children with type 1 diabetes and its association with serum IL-6 level.

Published in Mediators of Inflammation

ISSN: 0962-9351 (Print); 1466-1861 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://onlinelibrary.wiley.com/journal/4792

About the journal