Sensors (Aug 2021)

Feasibility Study of a Time-of-Flight Brain Positron Emission Tomography Employing Individual Channel Readout Electronics

  • Kuntai Park,
  • Jiwoong Jung,
  • Yong Choi,
  • Hyuntae Leem,
  • Yeonkyeong Kim

DOI
https://doi.org/10.3390/s21165566
Journal volume & issue
Vol. 21, no. 16
p. 5566

Abstract

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The purpose of this study was to investigate the feasibility of a time-of-flight (TOF) brain positron emission tomography (PET) providing high-quality images. It consisted of 30 detector blocks arranged in a ring with a diameter of 257 mm and an axial field of view of 52.2 mm. Each detector block was composed of two detector modules and two application-specific integrated circuit (ASIC) chips. The detector module was composed of an 8 × 8 array of 3 × 3 mm2 multi-pixel photon counters and an 8 × 8 array of 3.11 × 3.11 × 15 mm3 lutetium yttrium oxyorthosilicate scintillators. The 64-channel individual readout ASIC was used to acquire the position, energy, and time information of a detected gamma ray. A coincidence timing resolution of 187 ps full width at half maximum (FWHM) was achieved using a pair of channels of two detector modules. The energy resolution and spatial resolution were 6.6 ± 0.6% FWHM (without energy nonlinearity correction) and 2.5 mm FWHM, respectively. The results of this study demonstrate that the developed TOF brain PET could provide excellent performance, allowing for a reduction in radiation dose or scanning time for brain imaging due to improved sensitivity and signal-to-noise ratio.

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