Oxidative stress in dogs with cardiorenal syndrome caused by endocardiosis

Abstract

Oxidative stress and decreased antioxidant defense were registered in dogs with endocardiosis. Complication of underlying pathology in the form of cardiorenal syndrome leads to aggravation of lipid peroxidation processes and causes further decrease in activity of enzymes of antioxidant defense system of animal organism. The aim of the study was to evaluate the pathophysiological significance of oxidative stress in the processes of formation and progression of cardiorenal syndrome in dogs with endocardiosis. Concentration of malondialdehyde, ceruloplasmin, diene conjugates, activity of superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase were measured in venous blood serum samples from 24 dogs with uncomplicated forms of endocardiosis, 31 dogs with endocardiosis complicated by cardiorenal syndrome, and 22 healthy dogs. Compared with the group of healthy dogs, dogs with endocardiosis were diagnosed with statistically significantly higher median of serum concentrations of malondialdehyde, ceruloplasmin, diene conjugates, as well as statistically significantly lower activity of superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase, which indicates activation and progression of lipid peroxidation processes against the background of simultaneous decrease in parameters of antioxidant defense system. Presence of cardiorenal syndrome in dogs with endocardiosis led to a sharp increase in manifestations of oxidative stress, which should be considered by clinicians when optimizing therapeutic and preventive measures. Lipid peroxidation products, as well as indicators of enzyme systems of antioxidant defense can be used as potential biomarkers of the development of cardiorenal complications in dogs with endocardiosis.

Keywords

• cardiorenal syndrome
• pathogenesis
• biochemistry
• pathochemistry
• dogs
• endocardiosis
• heart failure