PROLONGED MASSIVE POLYURIA AFTER RENAL TRANSPLANTATION

Abstract

Clinical case of prolonged massive polyuria in patient after renal transplantation is represented in this article. Polyuria lasted for a forty days after kidney transplantation, the larges amount of urine output was 55 litres per day. Analysis of transplant biopsy revealed acute tubular necrosis, initial arteriolosclerosis and suspected acute rejection. Doppler ultrasound study and perfusion scintigraphy detected no pathology. At first we tried to decrease the volume of infusion and fluid intake. Also we performed pulse therapy with methylprednisolone. However, these efforts were not effective. Using of a large doses of «Minerin» (posterior pituitary antidiuretic factor) allowed to decrease and stabilize the volume of urine output. The patient was discharge from clinic on day 42 after transplantation.

Keywords

• polyuria
• kidney transplantation
• tubular necrosis