Drug-resistant focal epilepsy in children is associated with increased modal controllability of the whole brain and epileptogenic regions

Aswin Chari; Kiran K. Seunarine; Xiaosong He; Martin M. Tisdall; Christopher A. Clark; Dani S. Bassett; Rod C. Scott; Richard E. Rosch

doi:10.1038/s42003-022-03342-8

Communications Biology (Apr 2022)

Drug-resistant focal epilepsy in children is associated with increased modal controllability of the whole brain and epileptogenic regions

Aswin Chari,
Kiran K. Seunarine,
Xiaosong He,
Martin M. Tisdall,
Christopher A. Clark,
Dani S. Bassett,
Rod C. Scott,
Richard E. Rosch

Affiliations

Aswin Chari: Developmental Neurosciences, Great Ormond Street Institute of Child Health, University College London
Kiran K. Seunarine: Developmental Neurosciences, Great Ormond Street Institute of Child Health, University College London
Xiaosong He: Department of Bioengineering, Electrical & Systems Engineering, Physics & Astronomy, Neurology, and Psychiatry, University of Pennsylvania
Martin M. Tisdall: Developmental Neurosciences, Great Ormond Street Institute of Child Health, University College London
Christopher A. Clark: Developmental Neurosciences, Great Ormond Street Institute of Child Health, University College London
Dani S. Bassett: Department of Bioengineering, Electrical & Systems Engineering, Physics & Astronomy, Neurology, and Psychiatry, University of Pennsylvania
Rod C. Scott: Developmental Neurosciences, Great Ormond Street Institute of Child Health, University College London
Richard E. Rosch: Department of Bioengineering, Electrical & Systems Engineering, Physics & Astronomy, Neurology, and Psychiatry, University of Pennsylvania

DOI: https://doi.org/10.1038/s42003-022-03342-8
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 14

Abstract

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Children with drug-resistant epilepsy exhibit distinct structural connectomes and changes in network controllability from healthy controls, providing further insight into the pathophysiology of this disease.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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