Transcriptome analysis identifies CCDC86 as a new potential Head and Neck Squamous Cell Carcinoma biomarker

Abstract

OBJECTIVES: Overall, this comprehensive analysis aims to evaluate the expression profile of CCDC86 in Head and Neck Squamous Cell Carcinoma, providing insights into its potential as a diagnostic biomarker. METHODS: Initially, we conducted transcriptomic integration analysis to examine CCDC86 expression in HNSCC using various datasets (RNA-seq) obtained from the gene expression profiling interactive analysis database. We also established the diagnostic significance of CCDC86 and coregulated genes in HNSCC through the Kaplan–Meier Plotter. RESULTS: Initially, we detected elevated levels of CCDC86 in HNSCC, which correlated with lower survival rates (p=<0.001). We also identified seven genes coregulated with CCDC86 that were also overexpressed in HNSCC in comparison with normal tissues. CONCLUSIONS: For the first time, our findings suggest that CCDC86 can be a new emerging biomarker with promising therapeutic values to HNSCC patients. IMPLICATIONS: No further implications other than specified in conclusion.