Nature Communications (Feb 2019)
Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism
- Armand Valsesia,
- Qiao-Ping Wang,
- Nele Gheldof,
- Jérôme Carayol,
- Hélène Ruffieux,
- Teleri Clark,
- Victoria Shenton,
- Lisa J. Oyston,
- Gregory Lefebvre,
- Sylviane Metairon,
- Christian Chabert,
- Ondine Walter,
- Polina Mironova,
- Paulina Lau,
- Patrick Descombes,
- Nathalie Viguerie,
- Dominique Langin,
- Mary-Ellen Harper,
- Arne Astrup,
- Wim H. Saris,
- Robert Dent,
- Greg G. Neely,
- Jörg Hager
Affiliations
- Armand Valsesia
- Nestlé Institute of Health Sciences
- Qiao-Ping Wang
- Functional Genomics group, Charles Perkins Centre, University of Sydney
- Nele Gheldof
- Nestlé Institute of Health Sciences
- Jérôme Carayol
- Nestlé Institute of Health Sciences
- Hélène Ruffieux
- Nestlé Institute of Health Sciences
- Teleri Clark
- Functional Genomics group, Charles Perkins Centre, University of Sydney
- Victoria Shenton
- Functional Genomics group, Charles Perkins Centre, University of Sydney
- Lisa J. Oyston
- Functional Genomics group, Charles Perkins Centre, University of Sydney
- Gregory Lefebvre
- Nestlé Institute of Health Sciences
- Sylviane Metairon
- Nestlé Institute of Health Sciences
- Christian Chabert
- Nestlé Institute of Health Sciences
- Ondine Walter
- Nestlé Institute of Health Sciences
- Polina Mironova
- Nestlé Institute of Health Sciences
- Paulina Lau
- Ottawa Hospital Weight Management Clinic, The Ottawa Hospital
- Patrick Descombes
- Nestlé Institute of Health Sciences
- Nathalie Viguerie
- Institute of Metabolic and Cardiovascular Diseases, INSERM, Paul Sabatier University, UMR 1048, Obesity Research Laboratory, University of Toulouse
- Dominique Langin
- Institute of Metabolic and Cardiovascular Diseases, INSERM, Paul Sabatier University, UMR 1048, Obesity Research Laboratory, University of Toulouse
- Mary-Ellen Harper
- Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa
- Arne Astrup
- Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen
- Wim H. Saris
- Department of Human Biology, NUTRIM, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+(MUMC+)
- Robert Dent
- Ecole Polytechnique Fédérale de Lausanne (EPFL)
- Greg G. Neely
- Functional Genomics group, Charles Perkins Centre, University of Sydney
- Jörg Hager
- Nestlé Institute of Health Sciences
- DOI
- https://doi.org/10.1038/s41467-019-08492-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 10
Abstract
Individuals show large variability in their capacity to lose weight and maintain this weight. Here, the authors perform GWAS in two weight loss intervention cohorts and identify two genetic loci associated with weight loss that are taken forward for Bayesian fine-mapping and functional assessment in flies.
