(S)-3-Chloro-4-(4-ethylpiperazin-1-yl)-5-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]furan-2(5H)-one

Abstract

The title compound, C20H33ClN2O3, was obtained via a tandem asymmetric Michael addition–elimination reaction of 3,4-dichloro-5-(S)-(l-menthyloxy)furan-2(5H)-one and 1-ethylpiperazine in the presence of potassium fluoride. The molecular structure contains an approximately planar five-membered furanone ring [maximum atomic deviation = 0.024 (2) Å] and two six-membered rings adopting chair conformations. Weak intermolecular C—H...O hydrogen bonding is present in the crystal structure.