Nature Communications (Sep 2021)
Dynamics of the compartmentalized Streptomyces chromosome during metabolic differentiation
- Virginia S. Lioy,
- Jean-Noël Lorenzi,
- Soumaya Najah,
- Thibault Poinsignon,
- Hervé Leh,
- Corinne Saulnier,
- Bertrand Aigle,
- Sylvie Lautru,
- Annabelle Thibessard,
- Olivier Lespinet,
- Pierre Leblond,
- Yan Jaszczyszyn,
- Kevin Gorrichon,
- Nelle Varoquaux,
- Ivan Junier,
- Frédéric Boccard,
- Jean-Luc Pernodet,
- Stéphanie Bury-Moné
Affiliations
- Virginia S. Lioy
- Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC)
- Jean-Noël Lorenzi
- Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC)
- Soumaya Najah
- Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC)
- Thibault Poinsignon
- Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC)
- Hervé Leh
- Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC)
- Corinne Saulnier
- Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC)
- Bertrand Aigle
- Université de Lorraine, INRAE, DynAMic
- Sylvie Lautru
- Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC)
- Annabelle Thibessard
- Université de Lorraine, INRAE, DynAMic
- Olivier Lespinet
- Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC)
- Pierre Leblond
- Université de Lorraine, INRAE, DynAMic
- Yan Jaszczyszyn
- Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC)
- Kevin Gorrichon
- Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC)
- Nelle Varoquaux
- Université Grenoble Alpes, CNRS, Grenoble INP, TIMC-IMAG
- Ivan Junier
- Université Grenoble Alpes, CNRS, Grenoble INP, TIMC-IMAG
- Frédéric Boccard
- Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC)
- Jean-Luc Pernodet
- Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC)
- Stéphanie Bury-Moné
- Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC)
- DOI
- https://doi.org/10.1038/s41467-021-25462-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Streptomyces bacteria have a linear chromosome, with core genes located in the central region and gene clusters for specialized metabolite biosynthesis found in the ‘arms’. Here, Lioy et al. show that such chromosome structure correlates with genetic compartmentalization, and the onset of metabolic differentiation is accompanied by a rearrangement of chromosome architecture.
