Nature Communications (Apr 2016)
GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate
- Inge Van de Walle,
- Anne-Catherine Dolens,
- Kaat Durinck,
- Katrien De Mulder,
- Wouter Van Loocke,
- Sagar Damle,
- Els Waegemans,
- Jelle De Medts,
- Imke Velghe,
- Magda De Smedt,
- Bart Vandekerckhove,
- Tessa Kerre,
- Jean Plum,
- Georges Leclercq,
- Ellen V. Rothenberg,
- Pieter Van Vlierberghe,
- Frank Speleman,
- Tom Taghon
Affiliations
- Inge Van de Walle
- Department of Clinical Chemistry, Faculty of Medicine and Health Sciences, Microbiology and Immunology, Ghent University, University Hospital Ghent
- Anne-Catherine Dolens
- Department of Clinical Chemistry, Faculty of Medicine and Health Sciences, Microbiology and Immunology, Ghent University, University Hospital Ghent
- Kaat Durinck
- Center for Medical Genetics, Ghent University, University Hospital Ghent
- Katrien De Mulder
- Department of Clinical Chemistry, Faculty of Medicine and Health Sciences, Microbiology and Immunology, Ghent University, University Hospital Ghent
- Wouter Van Loocke
- Center for Medical Genetics, Ghent University, University Hospital Ghent
- Sagar Damle
- Division of Biology & Biological Engineering, California Institute of Technology
- Els Waegemans
- Department of Clinical Chemistry, Faculty of Medicine and Health Sciences, Microbiology and Immunology, Ghent University, University Hospital Ghent
- Jelle De Medts
- Department of Clinical Chemistry, Faculty of Medicine and Health Sciences, Microbiology and Immunology, Ghent University, University Hospital Ghent
- Imke Velghe
- Department of Clinical Chemistry, Faculty of Medicine and Health Sciences, Microbiology and Immunology, Ghent University, University Hospital Ghent
- Magda De Smedt
- Department of Clinical Chemistry, Faculty of Medicine and Health Sciences, Microbiology and Immunology, Ghent University, University Hospital Ghent
- Bart Vandekerckhove
- Department of Clinical Chemistry, Faculty of Medicine and Health Sciences, Microbiology and Immunology, Ghent University, University Hospital Ghent
- Tessa Kerre
- Department of Clinical Chemistry, Faculty of Medicine and Health Sciences, Microbiology and Immunology, Ghent University, University Hospital Ghent
- Jean Plum
- Department of Clinical Chemistry, Faculty of Medicine and Health Sciences, Microbiology and Immunology, Ghent University, University Hospital Ghent
- Georges Leclercq
- Department of Clinical Chemistry, Faculty of Medicine and Health Sciences, Microbiology and Immunology, Ghent University, University Hospital Ghent
- Ellen V. Rothenberg
- Division of Biology & Biological Engineering, California Institute of Technology
- Pieter Van Vlierberghe
- Center for Medical Genetics, Ghent University, University Hospital Ghent
- Frank Speleman
- Center for Medical Genetics, Ghent University, University Hospital Ghent
- Tom Taghon
- Department of Clinical Chemistry, Faculty of Medicine and Health Sciences, Microbiology and Immunology, Ghent University, University Hospital Ghent
- DOI
- https://doi.org/10.1038/ncomms11171
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
Strong Notch signalling promotes initial T cell lineage specification of lymphoid progenitors but is also permissive for thymic natural killer (NK) cell development. Here the authors show that GATA3 directs human T-lineage commitment by modulating Notch activity and repressing the NK programme.
