2-Methylpropan-2-ammonium [(3<i>R</i>,5<i>R</i>)-7-[(1<i>S</i>,2<i>S</i>,6<i>S</i>,8<i>S</i>,8<i>aR</i>)-6-hydroxy-2-methyl-8-[(2<i>S</i>)-2-methylbutanoyl]oxy-1,2,6,7,8,8<i>a</i>-hexahydronaphthalen-1-yl]-3,5-heptanoate

Abstract

Pravastatin is a popular statin agent with applications in the treatment of cardiovascular diseases for patients with an abnormal lipid panel. The starting form of pravastatin is amorphous and following recrystallization, it becomes a crystalline solid with tert-butylamine salt molecules embedded within the lattice. Its molecular and crystal structure were elucidated based on single-crystal X-ray diffraction and characterized by ss-NMR.

Keywords

• pravastatin
• statin
• crystal structure
• salt