Nature Communications (Jun 2021)
Stepwise maturation of the peptidyl transferase region of human mitoribosomes
Abstract
Mammalian mitoribosomes feature dramatically reduced ribosomal RNAs and follow mitochondria specific assembly pathways. Here the authors describe the process of human mitochondrial ribosome maturation that results in the formation of the ribosomal active site region, including the peptidyl transferase loop and the two tRNA-binding loops.