Nature Communications (Jun 2021)

Stepwise maturation of the peptidyl transferase region of human mitoribosomes

  • Tea Lenarčič,
  • Mateusz Jaskolowski,
  • Marc Leibundgut,
  • Alain Scaiola,
  • Tanja Schönhut,
  • Martin Saurer,
  • Richard G. Lee,
  • Oliver Rackham,
  • Aleksandra Filipovska,
  • Nenad Ban

DOI
https://doi.org/10.1038/s41467-021-23811-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 8

Abstract

Read online

Mammalian mitoribosomes feature dramatically reduced ribosomal RNAs and follow mitochondria specific assembly pathways. Here the authors describe the process of human mitochondrial ribosome maturation that results in the formation of the ribosomal active site region, including the peptidyl transferase loop and the two tRNA-binding loops.