Nature Communications (Nov 2017)
Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations
- Wilton B. Williams,
- Jinsong Zhang,
- Chuancang Jiang,
- Nathan I. Nicely,
- Daniela Fera,
- Kan Luo,
- M. Anthony Moody,
- Hua-Xin Liao,
- S. Munir Alam,
- Thomas B. Kepler,
- Akshaya Ramesh,
- Kevin Wiehe,
- James A. Holland,
- Todd Bradley,
- Nathan Vandergrift,
- Kevin O. Saunders,
- Robert Parks,
- Andrew Foulger,
- Shi-Mao Xia,
- Mattia Bonsignori,
- David C. Montefiori,
- Mark Louder,
- Amanda Eaton,
- Sampa Santra,
- Richard Scearce,
- Laura Sutherland,
- Amanda Newman,
- Hilary Bouton-Verville,
- Cindy Bowman,
- Howard Bomze,
- Feng Gao,
- Dawn J. Marshall,
- John F. Whitesides,
- Xiaoyan Nie,
- Garnett Kelsoe,
- Steven G. Reed,
- Christopher B. Fox,
- Kim Clary,
- Marguerite Koutsoukos,
- David Franco,
- John R. Mascola,
- Stephen C. Harrison,
- Barton F. Haynes,
- Laurent Verkoczy
Affiliations
- Wilton B. Williams
- Duke Human Vaccine Institute, Duke University School of Medicine
- Jinsong Zhang
- Duke Human Vaccine Institute, Duke University School of Medicine
- Chuancang Jiang
- Duke Human Vaccine Institute, Duke University School of Medicine
- Nathan I. Nicely
- Duke Human Vaccine Institute, Duke University School of Medicine
- Daniela Fera
- Boston Children’s Hospital and Harvard Medical School
- Kan Luo
- Duke Human Vaccine Institute, Duke University School of Medicine
- M. Anthony Moody
- Duke Human Vaccine Institute, Duke University School of Medicine
- Hua-Xin Liao
- Duke Human Vaccine Institute, Duke University School of Medicine
- S. Munir Alam
- Duke Human Vaccine Institute, Duke University School of Medicine
- Thomas B. Kepler
- Boston University School of Medicine
- Akshaya Ramesh
- Boston University School of Medicine
- Kevin Wiehe
- Duke Human Vaccine Institute, Duke University School of Medicine
- James A. Holland
- Duke Human Vaccine Institute, Duke University School of Medicine
- Todd Bradley
- Duke Human Vaccine Institute, Duke University School of Medicine
- Nathan Vandergrift
- Duke Human Vaccine Institute, Duke University School of Medicine
- Kevin O. Saunders
- Duke Human Vaccine Institute, Duke University School of Medicine
- Robert Parks
- Duke Human Vaccine Institute, Duke University School of Medicine
- Andrew Foulger
- Duke Human Vaccine Institute, Duke University School of Medicine
- Shi-Mao Xia
- Duke Human Vaccine Institute, Duke University School of Medicine
- Mattia Bonsignori
- Duke Human Vaccine Institute, Duke University School of Medicine
- David C. Montefiori
- Duke Human Vaccine Institute, Duke University School of Medicine
- Mark Louder
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institute of Health
- Amanda Eaton
- Duke Human Vaccine Institute, Duke University School of Medicine
- Sampa Santra
- Boston Children’s Hospital and Harvard Medical School
- Richard Scearce
- Duke Human Vaccine Institute, Duke University School of Medicine
- Laura Sutherland
- Duke Human Vaccine Institute, Duke University School of Medicine
- Amanda Newman
- Duke Human Vaccine Institute, Duke University School of Medicine
- Hilary Bouton-Verville
- Duke Human Vaccine Institute, Duke University School of Medicine
- Cindy Bowman
- Duke Human Vaccine Institute, Duke University School of Medicine
- Howard Bomze
- Duke Human Vaccine Institute, Duke University School of Medicine
- Feng Gao
- Duke Human Vaccine Institute, Duke University School of Medicine
- Dawn J. Marshall
- Duke Human Vaccine Institute, Duke University School of Medicine
- John F. Whitesides
- Duke Human Vaccine Institute, Duke University School of Medicine
- Xiaoyan Nie
- Department of Immunology, Duke University
- Garnett Kelsoe
- Duke Human Vaccine Institute, Duke University School of Medicine
- Steven G. Reed
- Infectious Disease Research Institute
- Christopher B. Fox
- Infectious Disease Research Institute
- Kim Clary
- Infectious Disease Research Institute
- Marguerite Koutsoukos
- GSK Vaccines
- David Franco
- GSK Vaccines
- John R. Mascola
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institute of Health
- Stephen C. Harrison
- Boston Children’s Hospital and Harvard Medical School
- Barton F. Haynes
- Duke Human Vaccine Institute, Duke University School of Medicine
- Laurent Verkoczy
- Duke Human Vaccine Institute, Duke University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-017-01336-3
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 20
Abstract
An efficient HIV-1 vaccine will likely depend on eliciting broadly neutralizing antibodies (bnAb). Here the authors analyze the B cell repertoire in macaques and knock-in mice in response to sequential immunization with Env variants that induce a bnAb targeting the CD4-binding site of Env in a HIV-1 infected individual.
