The peculiarities of eosinophil apoptosis damage in patients with severe therapy-resistant bronchial asthma

Abstract

The study aim: to investigate the dynamics of transcription factor p53, proapoptoic (bax, bcl-XS), antiapoptotic (bcl-2, bcl-XL) effectors, IL-5 expression in peripheral blood eosinophils of patients with severe therapy-resistant bronchial asthma (BA). Methods: clinical, functional, allergologic observation, the study of apoptosis effectors expression (Polymerase Chain Reaction). Material: 60 patients with severe BA. Results: low p53 expression and eosinophils apoptosis depression were revealed in therapy-resistant asthmatics. Conclusion: eosinophil apoptosis disregulation – the key mechanism of persistent inflammation of the airways in therapy-resistant BA.

Keywords

• терапевтически-резистентная тяжелая бронхиальная астма
• эозинофил
• апоптоз
• р53
• ил-5
• bcl-2
• bax