PHARMACOLOGICAL NEPHROPROTECTION IN CHRONIC KIDNEY DISEASE: CURRENT OPPORTUNITIES AND PERSPECTIVES (REVIEW OF FOREIGN LITERATURE)

Abstract

A brief literature review analyses pharmacoprotective strategy in most widespread forms of chronic kidney disease: metabolic syndrome, hypertensive angionephrosclerosis, diabetic and non-diabetic nephropathy. Nephroprotective properties of the blockers of rennin-angiotensin-aldosteron system and other antiadrenergic drugs, diuretics, hypolipidemic, antianemic and hypouricemic drugs, active metabolites of vitamin D, metphormine and glytasones are reviewed. The highest efficacy of combined pharmaconephroprotection is demonstrated.

Keywords

• chronic kidney disease
• inhibitors of ace
• blockers of angiotensin ii receptors
• blockers of calcium channels
• saluretics
• spironolactones
• statins
• erythropoietin
• allopurinol
• paricalcitol