Comparison of Coagulation Parameters between Severe and Non-severe COVID-19 Patients Treated in a Tertiary Hospital in Indonesia

Abstract

Objective: To determine the differences in coagulation features in patients with severe versus non-severe COVID-19. Method: During the period of the study from July 2020 to June 2021, 371 COVID-19 patients were treated at Dr. Hasan Sadikin Hospital. These patients were divided into two groups based on the WHO critera into severe COVID-19 with clinical signs such as severe acute respiratory syndrome to respiratory failure and non-severe cases with no respiratory symptoms. Data analyzed were Prothrombin Time (PT), Activated Partial Thromboplastin Time (aPTT), International Normalized Ratio (INR), fibrinogen, D-dimer, and platelet count. Results: Median INR was significantly higher in patients with severe cases than in non-severe cases (1.04 vs. 0.94, p0.652 and 246 vs. 242 x103/mm3, p>0.924, respectively). Conclusions: The INR, PT, fibrinogen, and D-dimer can be considered as features that can be used to predict the severity of the disease and to choose the proper treatment for COVID-19 patients.

Keywords

• coagulopathy disorders, covid-19, severe acute respiratory syndrome, non-severe acute respiratory syndrome