IMMUNOPROTEOMICS OF INFECTIOUS ENDOCARDITIS OF NATIVE HEARTVALVES

Abstract

Abstract. The aim of present study was to analyze the most commonly detected blood plasma immune proteins, that reflect molecular pathways in development of infectious endocarditis of native valves, together with analysis of marker proteins of disease on the base of modern technological platform for clinical proteomics. Ninety-nine patients with infectious endocarditis of native heart valves were included into the study. All the patients were examined according to hospital assessment protocol, including clinical, laboratory and instrumental methods of evaluation. Separation and identification of proteins of microorganisms in blood and materials taken at surgery, detection of proteins related to functioning of immune system, were carried out using new methods of clinical proteomics. We have revealed same proteins, that are specific of pathogens causing infectious endocarditis, that thus representing immunogenic determinants and defining a systemic immune response in the patients.

Keywords

• infectious endocarditis
• clinical proteomics
• mass-spectrometry