A Comprehensive Review of the Therapeutic Value of Urine-Derived Stem Cells

Qian Zhou; Yiyu Cheng; Fang Sun; Jie Shen; M. I. Nasser; Ping Zhu; Xueyan Zhang; Yuxiang Li; Guangming Yin; Yuequn Wang; Xiushan Wu; Xiushan Wu; Mingyi Zhao; Mingyi Zhao

doi:10.3389/fgene.2021.781597

Frontiers in Genetics (Jan 2022)

A Comprehensive Review of the Therapeutic Value of Urine-Derived Stem Cells

Qian Zhou,
Yiyu Cheng,
Fang Sun,
Jie Shen,
M. I. Nasser,
Ping Zhu,
Xueyan Zhang,
Yuxiang Li,
Guangming Yin,
Yuequn Wang,
Xiushan Wu,
Xiushan Wu,
Mingyi Zhao,
Mingyi Zhao

Affiliations

Qian Zhou: Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China
Yiyu Cheng: Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China
Fang Sun: Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China
Jie Shen: Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China
M. I. Nasser: Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Ping Zhu: Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Xueyan Zhang: Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China
Yuxiang Li: Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, China
Guangming Yin: Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, China
Yuequn Wang: The Center for Heart Development, State Key Laboratory of Development Biology of Freshwater Fish, Key Laboratory of MOE for Development Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, Changsha, China
Xiushan Wu: Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Xiushan Wu: The Center for Heart Development, State Key Laboratory of Development Biology of Freshwater Fish, Key Laboratory of MOE for Development Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, Changsha, China
Mingyi Zhao: Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China
Mingyi Zhao: Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China

DOI: https://doi.org/10.3389/fgene.2021.781597
Journal volume & issue: Vol. 12

Abstract

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Stem cells possess regenerative powers and multidirectional differentiation potential and play an important role in disease treatment and basic medical research. Urine-derived stem cells (USCs) represent a newly discovered type of stem cell with biological characteristics similar to those of mesenchymal stromal cells (MSCs), including their doubling time and immunophenotype. USCs are noninvasive and can be readily obtained from voided urine and steadily cultured. Based on advances in this field, USCs and their secretions have increasingly emerged as ideal sources. USCs may play regulatory roles in the cellular immune system, oxidative stress, revascularization, apoptosis and autophagy. This review summarizes the applications of USCs in tissue regeneration and various disease treatments. Furthermore, by analysing their limitations, we anticipate the development of more feasible therapeutic strategies to promote USC-based individualized treatment.

Published in Frontiers in Genetics

ISSN: 1664-8021 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Genetics
Website: http://journal.frontiersin.org/journal/genetics

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