Management of hemolytic transfusion reactions in a patient with chronic myelomonocytic leukemia and rare antibodies: A case report

Grace S. Park; Himachandana Atluri; Courtney D. DiNardo; Bryan Guillroy; Jean Horak; Effrosyni Apostolidou; Maryam Buni; Guillermo Montalban Bravo; Naveen Pemmaraju

Leukemia Research Reports (Jan 2025)

Management of hemolytic transfusion reactions in a patient with chronic myelomonocytic leukemia and rare antibodies: A case report

Grace S. Park,
Himachandana Atluri,
Courtney D. DiNardo,
Bryan Guillroy,
Jean Horak,
Effrosyni Apostolidou,
Maryam Buni,
Guillermo Montalban Bravo,
Naveen Pemmaraju

Affiliations

Grace S. Park: Department of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston, TX, United States
Himachandana Atluri: Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States
Courtney D. DiNardo: Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States
Bryan Guillroy: Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States
Jean Horak: Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States
Effrosyni Apostolidou: Department of Benign Hematology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States
Maryam Buni: Department of Rheumatology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States
Guillermo Montalban Bravo: Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States
Naveen Pemmaraju: Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States; Corresponding author at: Department of Leukemia, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, United States.

Journal volume & issue: Vol. 23
p. 100485

Abstract

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Delayed hemolytic transfusion reaction (DHTR) poses a significant challenge in patients receiving blood transfusions. This case report highlights the complexities of managing DHTR in a newly diagnosed chronic myelomonocytic leukemia (CMML) patient with clinically significant JKa and little c antibodies during induction chemotherapy. A 46-year-old woman with CMML-2 who presented for induction chemotherapy was found to have hemolytic anemia. Due to presence of JKa and little c antibodies, she required intensive monitoring and supportive care measures. The coexistence of JKa and little c antibodies complicates transfusion management and chemotherapy tolerance in CMML patients.

Published in Leukemia Research Reports

ISSN: 2213-0489 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://www.journals.elsevier.com/leukemia-research-reports/

About the journal

Abstract

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