Frontiers in Endocrinology (Oct 2023)
Efficiency and safety of vitrification of surplus oocytes following superovulation: a comparison of different clinical indications of oocyte cryopreservation in IVF/ICSI cycles
- Xiao Fu,
- Xiao Fu,
- Xiao Fu,
- Xiao Fu,
- Xiao Fu,
- Xiao Fu,
- Yiting Zhang,
- Yiting Zhang,
- Yiting Zhang,
- Yiting Zhang,
- Yiting Zhang,
- Yiting Zhang,
- Shuli Gao,
- Shuli Gao,
- Shuli Gao,
- Shuli Gao,
- Shuli Gao,
- Shuli Gao,
- Shuzhe Gao,
- Shuzhe Gao,
- Shuzhe Gao,
- Shuzhe Gao,
- Shuzhe Gao,
- Shuzhe Gao,
- Meng Zhang,
- Meng Zhang,
- Meng Zhang,
- Meng Zhang,
- Meng Zhang,
- Meng Zhang,
- Shanshan Gao,
- Shanshan Gao,
- Shanshan Gao,
- Shanshan Gao,
- Shanshan Gao,
- Shanshan Gao,
- Jinlong Ma,
- Jinlong Ma,
- Jinlong Ma,
- Jinlong Ma,
- Jinlong Ma,
- Jinlong Ma,
- Zi-Jiang Chen,
- Zi-Jiang Chen,
- Zi-Jiang Chen,
- Zi-Jiang Chen,
- Zi-Jiang Chen,
- Zi-Jiang Chen,
- Zi-Jiang Chen,
- Zi-Jiang Chen
Affiliations
- Xiao Fu
- Center for Reproductive Medicine, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
- Xiao Fu
- Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, China
- Xiao Fu
- Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, China
- Xiao Fu
- Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China
- Xiao Fu
- Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China
- Xiao Fu
- National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China
- Yiting Zhang
- Center for Reproductive Medicine, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
- Yiting Zhang
- Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, China
- Yiting Zhang
- Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, China
- Yiting Zhang
- Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China
- Yiting Zhang
- Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China
- Yiting Zhang
- National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China
- Shuli Gao
- Center for Reproductive Medicine, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
- Shuli Gao
- Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, China
- Shuli Gao
- Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, China
- Shuli Gao
- Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China
- Shuli Gao
- Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China
- Shuli Gao
- National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China
- Shuzhe Gao
- Center for Reproductive Medicine, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
- Shuzhe Gao
- Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, China
- Shuzhe Gao
- Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, China
- Shuzhe Gao
- Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China
- Shuzhe Gao
- Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China
- Shuzhe Gao
- National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China
- Meng Zhang
- Center for Reproductive Medicine, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
- Meng Zhang
- Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, China
- Meng Zhang
- Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, China
- Meng Zhang
- Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China
- Meng Zhang
- Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China
- Meng Zhang
- National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China
- Shanshan Gao
- Center for Reproductive Medicine, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
- Shanshan Gao
- Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, China
- Shanshan Gao
- Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, China
- Shanshan Gao
- Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China
- Shanshan Gao
- Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China
- Shanshan Gao
- National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China
- Jinlong Ma
- Center for Reproductive Medicine, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
- Jinlong Ma
- Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, China
- Jinlong Ma
- Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, China
- Jinlong Ma
- Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China
- Jinlong Ma
- Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China
- Jinlong Ma
- National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China
- Zi-Jiang Chen
- Center for Reproductive Medicine, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
- Zi-Jiang Chen
- Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, China
- Zi-Jiang Chen
- Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, China
- Zi-Jiang Chen
- Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China
- Zi-Jiang Chen
- Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China
- Zi-Jiang Chen
- National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China
- Zi-Jiang Chen
- Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China
- Zi-Jiang Chen
- Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- DOI
- https://doi.org/10.3389/fendo.2023.1221308
- Journal volume & issue
-
Vol. 14
Abstract
ObjectiveTo evaluate the effectiveness and safety of utilizing the small number of remaining vitrified oocytes after the failure of adequate fresh sibling oocytes. The outcome of present study would provide more comprehensive information about possible benefits or disadvantage to cryopreserve supernumerary oocytes for patients who have plenty oocytes retrieved.MethodsThis retrospective cohort study included 791 IVF/ICSI cycles using 6344 oocytes that had been vitrified in the Reproductive Hospital affiliated to Shandong University between January 2013 and December 2019.They were divided into three groups: SOC group (supernumerary oocytes cryopreservation), relative-MOC group (relative male factor-oocyte cryopreservation), and absolute-MOC group (absolute male factor-oocyte cryopreservation). Laboratory and clinical outcomes were analysed, and multivariate regression analysis was used to study the effect of different indications of vitrification on CLBR.ResultsThe CLBR was highest in absolute-MOC, and lowest in SOC (39.0% vs 28.9%, P=0.006); however, after adjusting for confounding factors, the difference was not statistically significant. Multivariable regression analysis showed no impact of indications of vitrified oocytes on CLBR according to controlled age, BMI, preservation duration, use of donor sperm or not, use of PESA/TESA or not, number of oocytes retrieved, number of oocytes thawed, and oocyte survival rate. The preliminary data of safety showed no significant differences in the perinatal and neonatal outcoms after ET and FET between the SOC and MOC groups.ConclusionDifferent indications of vitrification did not affect CLBR. The CLBR of vitrified oocytes for different indications was correlated with age and number of warmed oocytes. For women who have plenty oocytes retrieved, the strategy of cryopreserving a small number of oocytes is a valuable option and might benefit them in the future. Additional data from autologous oocyte vitrification research employing a large-scale and variable-controlled methodology with extending follow-up will complement and clarify the current results.
Keywords
