Nature Communications (Dec 2017)
ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ
- Yu Zhang,
- Xian Guo,
- Wanyao Yan,
- Yan Chen,
- Mengxiang Ke,
- Cheng Cheng,
- Xiuqin Zhu,
- Weili Xue,
- Qiaoqiao Zhou,
- Ling Zheng,
- Shun Wang,
- Bin Wu,
- Xinran Liu,
- Liang Ma,
- Lianqi Huang,
- Kun Huang
Affiliations
- Yu Zhang
- Tongji School of Pharmacy, Huazhong University of Science & Technology
- Xian Guo
- Tongji School of Pharmacy, Huazhong University of Science & Technology
- Wanyao Yan
- Tongji School of Pharmacy, Huazhong University of Science & Technology
- Yan Chen
- Tongji School of Pharmacy, Huazhong University of Science & Technology
- Mengxiang Ke
- Tongji School of Pharmacy, Huazhong University of Science & Technology
- Cheng Cheng
- Tongji School of Pharmacy, Huazhong University of Science & Technology
- Xiuqin Zhu
- Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University
- Weili Xue
- Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University
- Qiaoqiao Zhou
- Tongji School of Pharmacy, Huazhong University of Science & Technology
- Ling Zheng
- Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University
- Shun Wang
- Department of Blood Transfusion, Wuhan Hospital of Traditional and Western Medicine
- Bin Wu
- Department of Blood Transfusion, Wuhan Hospital of Traditional and Western Medicine
- Xinran Liu
- Tongji School of Pharmacy, Huazhong University of Science & Technology
- Liang Ma
- Tongji School of Pharmacy, Huazhong University of Science & Technology
- Lianqi Huang
- Tongji School of Pharmacy, Huazhong University of Science & Technology
- Kun Huang
- Tongji School of Pharmacy, Huazhong University of Science & Technology
- DOI
- https://doi.org/10.1038/s41467-017-02355-w
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
NF-κB activation mediated by TNFα has a critical role in inflammation; however, the underlying mechanisms await further investigation. Here the authors show that selective autophagy regulates NF-κB activation via an ANGPTL8/p62-IKKγ signaling axis.
