The Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and motile forms in Plasmodium berghei

Ravish Rashpa; Natacha Klages; Domitille Schvartz; Carla Pasquarello; Mathieu Brochet

doi:10.1038/s41467-023-36999-8

Nature Communications (Mar 2023)

The Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and motile forms in Plasmodium berghei

Ravish Rashpa,
Natacha Klages,
Domitille Schvartz,
Carla Pasquarello,
Mathieu Brochet

Affiliations

Ravish Rashpa: University of Geneva, Faculty of Medicine, Department of Microbiology and Molecular Medicine
Natacha Klages: University of Geneva, Faculty of Medicine, Department of Microbiology and Molecular Medicine
Domitille Schvartz: University of Geneva, Faculty of Medicine, Proteomics Core Facility
Carla Pasquarello: University of Geneva, Faculty of Medicine, Proteomics Core Facility
Mathieu Brochet: University of Geneva, Faculty of Medicine, Department of Microbiology and Molecular Medicine

DOI: https://doi.org/10.1038/s41467-023-36999-8
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 18

Abstract

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Raspha et al. apply proteomics and different microscopy approaches to investigate the role of ubiquitination in the lifecycle progression of Plasmodium berghei. They describe the location and function of proteins linked to the conserved SKP1/Culin1/FBXO1 complex (SCF) – a member of the cullinRING E3 ligases (CRLs).

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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