Nature Communications (Nov 2022)

Prioritizing autoimmunity risk variants for functional analyses by fine-mapping mutations under natural selection

  • Vasili Pankratov,
  • Milyausha Yunusbaeva,
  • Sergei Ryakhovsky,
  • Maksym Zarodniuk,
  • Estonian Biobank Research Team,
  • Bayazit Yunusbayev

Journal volume & issue
Vol. 13, no. 1
pp. 1 – 13


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Immune genes under selection can shed light on phenotypes contributing to survival and modern inflammatory conditions. Here, the authors prioritize adaptive disease variants in 535 risk loci for 21 inflammatory conditions and report promising SNPs for functional studies with predictions of cell context and function.