Nature Communications (Aug 2021)

A genome-scale metabolic model of Saccharomyces cerevisiae that integrates expression constraints and reaction thermodynamics

  • Omid Oftadeh,
  • Pierre Salvy,
  • Maria Masid,
  • Maxime Curvat,
  • Ljubisa Miskovic,
  • Vassily Hatzimanikatis

DOI
https://doi.org/10.1038/s41467-021-25158-6
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

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Formulating metabolic networks mathematically can help researchers study metabolic diseases and optimize the production of industrially important molecules. Here, the authors propose a framework that allows to model eukaryotic metabolism considering gene expression and thermodynamic constraints.