Nature Communications (Oct 2022)
Genetic map of regional sulcal morphology in the human brain from UK biobank data
- Benjamin B. Sun,
- Stephanie J. Loomis,
- Fabrizio Pizzagalli,
- Natalia Shatokhina,
- Jodie N. Painter,
- Christopher N. Foley,
- Biogen Biobank Team,
- Megan E. Jensen,
- Donald G. McLaren,
- Sai Spandana Chintapalli,
- Alyssa H. Zhu,
- Daniel Dixon,
- Tasfiya Islam,
- Iyad Ba Gari,
- Heiko Runz,
- Sarah E. Medland,
- Paul M. Thompson,
- Neda Jahanshad,
- Christopher D. Whelan
Affiliations
- Benjamin B. Sun
- Translational Biology, Research & Development, Biogen Inc.
- Stephanie J. Loomis
- Translational Biology, Research & Development, Biogen Inc.
- Fabrizio Pizzagalli
- Department of Neuroscience “Rita Levi Montalcini”, University of Turin
- Natalia Shatokhina
- Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California
- Jodie N. Painter
- QIMR Berghofer Medical Research Institute
- Christopher N. Foley
- MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge
- Biogen Biobank Team
- Megan E. Jensen
- Clinical Sciences, Research & Development, Biogen Inc.
- Donald G. McLaren
- Clinical Sciences, Research & Development, Biogen Inc.
- Sai Spandana Chintapalli
- Department of Bioengineering, University of Pennsylvania
- Alyssa H. Zhu
- Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California
- Daniel Dixon
- Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California
- Tasfiya Islam
- Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California
- Iyad Ba Gari
- Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California
- Heiko Runz
- Translational Biology, Research & Development, Biogen Inc.
- Sarah E. Medland
- QIMR Berghofer Medical Research Institute
- Paul M. Thompson
- Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California
- Neda Jahanshad
- Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California
- Christopher D. Whelan
- Translational Biology, Research & Development, Biogen Inc.
- DOI
- https://doi.org/10.1038/s41467-022-33829-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Genetic associations with particular patterns of brain folding may provide insight into brain development and function. Here, the authors identify and replicate 388 genetic associations with brain sulcal morphology across 40,169 UK Biobank MRI scans, revealing insights into the processes guiding cortical development and genetic correlations with neuropsychiatric phenotypes.
