Nature Communications (May 2022)
Identification and characterization of a novel enhancer in the HTLV-1 proviral genome
- Misaki Matsuo,
- Takaharu Ueno,
- Kazuaki Monde,
- Kenji Sugata,
- Benjy Jek Yang Tan,
- Akhinur Rahman,
- Paola Miyazato,
- Kyosuke Uchiyama,
- Saiful Islam,
- Hiroo Katsuya,
- Shinsuke Nakajima,
- Masahito Tokunaga,
- Kisato Nosaka,
- Hiroyuki Hata,
- Atae Utsunomiya,
- Jun-ichi Fujisawa,
- Yorifumi Satou
Affiliations
- Misaki Matsuo
- Division of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto University
- Takaharu Ueno
- Department of Microbiology, Kansai Medical University
- Kazuaki Monde
- Department of Microbiology, Faculty of Life Sciences, Kumamoto University
- Kenji Sugata
- Division of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto University
- Benjy Jek Yang Tan
- Division of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto University
- Akhinur Rahman
- Division of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto University
- Paola Miyazato
- Division of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto University
- Kyosuke Uchiyama
- Division of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto University
- Saiful Islam
- Division of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto University
- Hiroo Katsuya
- Division of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto University
- Shinsuke Nakajima
- Department of Microbiology, Kansai Medical University
- Masahito Tokunaga
- Department of Hematology, Imamura General Hospital
- Kisato Nosaka
- Department of Hematology, Rheumatology and Infectious Disease, Kumamoto University Hospital
- Hiroyuki Hata
- Division of Informative Clinical Sciences, Faculty of Life Sciences, Kumamoto University
- Atae Utsunomiya
- Department of Hematology, Imamura General Hospital
- Jun-ichi Fujisawa
- Department of Microbiology, Kansai Medical University
- Yorifumi Satou
- Division of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto University
- DOI
- https://doi.org/10.1038/s41467-022-30029-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic virus with constantly active antisense transcription from the proviral genome. Here, Matsuo et al. perform proviral DNA-capture followed by high-throughput sequencing and identify a yet unknown viral enhancer in the middle of the HTLV-1 provirus.
