PROGNOSTIC ROLE OF CHRONIC HEART FAILURE SEVERITY MARKERS AND RISK STRATIFICATION IN PATIENTS AGED 75 YEARS OR OLDER: BNUP-AGE SURVIVAL MODEL (NEVA-75)

Abstract

To assess prognostic value of chronic heart failure (CHF) severity markers in patients aged over 74 years, and to optimise the risk stratification accordingly. This prospective study included 104 CHF patients aged 75 years or older, who were followed up for 2,5 years after hospital discharge. The effects of 150 clinical, instrumental, and laboratory parameters on survival were investigated. The survival over 2,5 years reached 30%. The main risk factors (RFs) of adverse outcome included age and levels of brain natriuretic peptide (BNUP). A prognostic model – BNUP-agE surVivAl model (NEVA-75) – was created. The main RFs of adverse outcome over 2,5 years of the follow-up were age and plasma BNUP levels. The model NEVA-75 could be used for assessing the prognosis and selecting the optimal therapeutic strategy in CHF patients aged over 74 years, who are discharged from hospital after CHF clinical stabilisation and are followed at a non-specialised polyclinic.

Keywords

• chronic heart failure prognosis
• advanced age
• brain natriuretic peptide
• neva-75 algorithm