Nature Communications (Oct 2020)

Non-invasive molecularly-specific millimeter-resolution manipulation of brain circuits by ultrasound-mediated aggregation and uncaging of drug carriers

  • Mehmet S. Ozdas,
  • Aagam S. Shah,
  • Paul M. Johnson,
  • Nisheet Patel,
  • Markus Marks,
  • Tansel Baran Yasar,
  • Urs Stalder,
  • Laurent Bigler,
  • Wolfger von der Behrens,
  • Shashank R. Sirsi,
  • Mehmet Fatih Yanik

DOI
https://doi.org/10.1038/s41467-020-18059-7
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

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Non-invasive manipulation of brain circuits with molecular and spatial specificity could revolutionize the treatment of brain disorders. Here, the authors remotely concentrate and deliver drugs to focal brain regions without compromising the blood-brain barrier using novel ultrasound sequences and drug carriers.