Genetic variants in the WNT signaling pathway are protectively associated with colorectal cancer in a Saudi population

Narasimha Reddy Parine; Nahla A. Azzam; Jilani Shaik; Abdulrahman M. Aljebreen; Othman Alharbi; Majid A. Almadi; Mohammad Alanazi; Zahid Khan

Saudi Journal of Biological Sciences (Feb 2019)

Genetic variants in the WNT signaling pathway are protectively associated with colorectal cancer in a Saudi population

Narasimha Reddy Parine,
Nahla A. Azzam,
Jilani Shaik,
Abdulrahman M. Aljebreen,
Othman Alharbi,
Majid A. Almadi,
Mohammad Alanazi,
Zahid Khan

Affiliations

Narasimha Reddy Parine: Genome Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia
Nahla A. Azzam: College of Medicine, King Saud University, Riyadh, Saudi Arabia; Division of Gastroenterology, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
Jilani Shaik: Genome Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia
Abdulrahman M. Aljebreen: College of Medicine, King Saud University, Riyadh, Saudi Arabia; Division of Gastroenterology, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
Othman Alharbi: College of Medicine, King Saud University, Riyadh, Saudi Arabia; Division of Gastroenterology, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
Majid A. Almadi: College of Medicine, King Saud University, Riyadh, Saudi Arabia; Division of Gastroenterology, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
Mohammad Alanazi: Genome Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia
Zahid Khan: Genome Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia; Corresponding author at: Genome Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.

Journal volume & issue: Vol. 26, no. 2
pp. 286 – 293

Abstract

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The Wnt/β-catenin signaling pathway has been etiologically implicated in the development and progression of colorectal cancer. We studied thirteen single nucleotide polymorphisms (SNPs) located in SFRP3 (rs7775), CTNNB1 (β-catenin) [rs4135385, rs13072632], APC (rs454886, rs459552), LRP6 (rs2075241, rs2284396), DKK4 (rs3763511), DKK3 (rs6485350), TCF4 (rs12255372) and AXIN2 (rs3923086, rs3923087, rs4791171) in patients with colorectal cancer (n = 122) and controls (n = 110). Evaluation of WNT pathway SNPs showed protective association for rs4135385, located in β-catenin. Additionally, variants in SFRP3 (rs7775) and LRP6 (rs2284396) which did not show any association in the overall analysis were significantly associated with female and old aged colorectal cancer patients, respectively. Keywords: WNT signaling pathway, Colorectal cancer, SFRP3, LRP6, β-catenin

Published in Saudi Journal of Biological Sciences

ISSN: 1319-562X (Print)
Publisher: Elsevier
Country of publisher: Saudi Arabia
LCC subjects: Science: Biology (General)
Website: http://www.journals.elsevier.com/saudi-journal-of-biological-sciences/

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