Phoenix dactylifera Polyphenols Ameliorates Monosodium Glutamate Induced Cell Damage in the Dentate Gyrus

Abstract

Background: Monosodium Glutamate (MSG) use is quite alarming considering the cascades of toxicity that arises from it. However, this study demonstrated the possible ameliorative activities of polyphenols of Phoenix dactylifera (PPD) on MSG-induced dentate gyrus degeneration in male adult Wistar rats. Aim and Objectives: To check the effects of PPD on MSG-induced dentate gyrus neuronal damage in adult male Wistar rats. Material and Methods: Groups A to D of adult male rats underwent 14-day treatment of Normal Saline (NS), 500 mg ̸ kg PPD, 4 mg ̸g of MSG only, and 4 mg ̸g MSG and 500 mg ̸ kg PPD (MSG+PPD) concurrently. Group E received 500 mg ̸ kg PPD for a 14-day period prior to another 14-day of 4 mg ̸ g MSG (PPD then MSG). Results: PPD was able to ameliorate the toxic effect of MSG as evidence of better cellular integrity, minimal cell vacuolations, minimized dispersed Nissl bodies and deeply stained Nissl bodies were observed upon PPD administration. It was also observed that it reduced the proliferation of reactive oxygen species, proteins and DNA damage in the cells of the dentate gyrus. Conclusion: The study concluded that PPD was able to ameliorate the degeneration induced by MSG in the dentate gyrus of Wistar rats.

Keywords

• phoenix dactylifera
• polyphenols
• monosodium glutamate
• dentate gyrus