The Chaperonopathies - Diseases with Defective Molecular Chaperones

Abstract

In the mid 1950's the Nobel Prize Laureate Christian B. Anfinsen from his research on the folding of ribonuclease A, began to concentrate on the problem of the relationship between structure and function in enzymes. On the basis of studies on ribonuclease, he proposed that the information determining the tertiary structure of a protein resides in the chemistry of its amino acid sequence....