Nature Communications (Feb 2018)
Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion
- Antonia Marazioti,
- Ioannis Lilis,
- Malamati Vreka,
- Hara Apostolopoulou,
- Argyro Kalogeropoulou,
- Ioanna Giopanou,
- Georgia A. Giotopoulou,
- Anthi C. Krontira,
- Marianthi Iliopoulou,
- Nikolaos I. Kanellakis,
- Theodora Agalioti,
- Anastasios D. Giannou,
- Celestial Jones-Paris,
- Yoichiro Iwakura,
- Dimitrios Kardamakis,
- Timothy S. Blackwell,
- Stavros Taraviras,
- Magda Spella,
- Georgios T. Stathopoulos
Affiliations
- Antonia Marazioti
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- Ioannis Lilis
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- Malamati Vreka
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- Hara Apostolopoulou
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- Argyro Kalogeropoulou
- Stem Cell Biology Laboratory, Department of Physiology, Faculty of Medicine, University of Patras
- Ioanna Giopanou
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- Georgia A. Giotopoulou
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- Anthi C. Krontira
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- Marianthi Iliopoulou
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- Nikolaos I. Kanellakis
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- Theodora Agalioti
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- Anastasios D. Giannou
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- Celestial Jones-Paris
- Division of Allergy, Pulmonary and Critical Care, Department of Internal Medicine, Vanderbilt University School of Medicine
- Yoichiro Iwakura
- Research Institute for Biomedical Sciences, Tokyo University of Science
- Dimitrios Kardamakis
- Department of Radiation Oncology and Stereotactic Radiotherapy, Faculty of Medicine, University of Patras
- Timothy S. Blackwell
- Division of Allergy, Pulmonary and Critical Care, Department of Internal Medicine, Vanderbilt University School of Medicine
- Stavros Taraviras
- Stem Cell Biology Laboratory, Department of Physiology, Faculty of Medicine, University of Patras
- Magda Spella
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- Georgios T. Stathopoulos
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- DOI
- https://doi.org/10.1038/s41467-018-03051-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
Malignant pleural effusion (MPE) is a life-threatening cancer-related disorder. Here, the authors show that KRAS-mutant tumor cells require IKKα, activated via host-provided IL-1β, to promote MPE development and that co-inhibition of both KRAS and IKKα ameliorates the development of MPE in mouse models.
