Young adult-onset, very slowly progressive cognitive decline with spastic paraparesis in Alzheimer’s disease with cotton wool plaques due to a novel presenilin1 G417S mutation

• Tomoko Miki,
• Osamu Yokota,
• Takashi Haraguchi,
• Takeshi Ikeuchi,
• Bin Zhu,
• Shintaro Takenoshita,
• Seishi Terada,
• Norihito Yamada

Affiliations

Tomoko Miki

Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

Osamu Yokota

Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

Takashi Haraguchi

Department of Neurology, National Hospital Organization Minami-Okayama Medical Center

Takeshi Ikeuchi

Department of Molecular Neuroscience, Brain Research Institute, Niigata University

Bin Zhu

Department of Molecular Neuroscience, Brain Research Institute, Niigata University

Shintaro Takenoshita

Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

Seishi Terada

Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

Norihito Yamada

Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences