AKAP95 regulates splicing through scaffolding RNAs and RNA processing factors

Jing Hu; Alireza Khodadadi-Jamayran; Miaowei Mao; Kushani Shah; Zhenhua Yang; Md Talat Nasim; Zefeng Wang; Hao Jiang

doi:10.1038/ncomms13347

Nature Communications (Nov 2016)

AKAP95 regulates splicing through scaffolding RNAs and RNA processing factors

Jing Hu,
Alireza Khodadadi-Jamayran,
Miaowei Mao,
Kushani Shah,
Zhenhua Yang,
Md Talat Nasim,
Zefeng Wang,
Hao Jiang

Affiliations

Jing Hu: Department of Biochemistry and Molecular Genetics, UAB Stem Cell Institute, University of Alabama at Birmingham School of Medicine
Alireza Khodadadi-Jamayran: Department of Biochemistry and Molecular Genetics, UAB Stem Cell Institute, University of Alabama at Birmingham School of Medicine
Miaowei Mao: Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina
Kushani Shah: Department of Biochemistry and Molecular Genetics, UAB Stem Cell Institute, University of Alabama at Birmingham School of Medicine
Zhenhua Yang: Department of Biochemistry and Molecular Genetics, UAB Stem Cell Institute, University of Alabama at Birmingham School of Medicine
Md Talat Nasim: University of Bradford School of Pharmacy
Zefeng Wang: Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina
Hao Jiang: Department of Biochemistry and Molecular Genetics, UAB Stem Cell Institute, University of Alabama at Birmingham School of Medicine

DOI: https://doi.org/10.1038/ncomms13347
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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The chromatin-associated protein AKAP95 is known for its chromatin-related functions including enhancing transcription. Here the authors show that AKAP95 interacts with the splicing regulatory factors as well as RNAs to regulate the inclusion of exons and pre-mRNA splicing.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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