Nature Communications (Oct 2017)
NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression
- Junyi Ju,
- Aiping Chen,
- Yexuan Deng,
- Ming Liu,
- Ying Wang,
- Yadong Wang,
- Min Nie,
- Chao Wang,
- Hong Ding,
- Bing Yao,
- Tao Gui,
- Xinyu Li,
- Zhen Xu,
- Chi Ma,
- Yong Song,
- Marc Kvansakul,
- Ke Zen,
- Chen-Yu Zhang,
- Cheng Luo,
- Ming Fang,
- David C. S. Huang,
- C. David Allis,
- Renxiang Tan,
- Changjiang Kathy Zeng,
- Jiwu Wei,
- Quan Zhao
Affiliations
- Junyi Ju
- The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
- Aiping Chen
- Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University
- Yexuan Deng
- The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
- Ming Liu
- The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
- Ying Wang
- The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
- Yadong Wang
- The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
- Min Nie
- The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
- Chao Wang
- Institute of Life Sciences, Southeast University
- Hong Ding
- Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Bing Yao
- The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
- Tao Gui
- The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
- Xinyu Li
- The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
- Zhen Xu
- Department of Medical Biology, The Walter and Eliza Hall Institute of Medical Research, University of Melbourne
- Chi Ma
- The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
- Yong Song
- Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University
- Marc Kvansakul
- Department of Biochemistry, La Trobe University
- Ke Zen
- The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
- Chen-Yu Zhang
- The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
- Cheng Luo
- Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Ming Fang
- Institute of Life Sciences, Southeast University
- David C. S. Huang
- Department of Medical Biology, The Walter and Eliza Hall Institute of Medical Research, University of Melbourne
- C. David Allis
- Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University
- Renxiang Tan
- The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
- Changjiang Kathy Zeng
- SQJ Biotechnologies Limited
- Jiwu Wei
- Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University
- Quan Zhao
- The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
- DOI
- https://doi.org/10.1038/s41467-017-00988-5
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.
