International Journal of General Medicine (Jun 2022)

Admission Levels of Serum P-Selectin and IL-6 Can Predict Development of Deep Venous Thrombosis in Hospitalized Covid-19 Patients

  • Farouk N,
  • Ashry WMO,
  • EL-Hagrasy HA,
  • Mohamed EF,
  • Eltrawy HH,
  • El-Nasser AM,
  • Shipl W,
  • El Attar S,
  • Kh Sakr L,
  • Abdel Wahab MA,
  • Abdelsalam EM,
  • Sharaf FA,
  • Ahmad IH

Journal volume & issue
Vol. Volume 15
pp. 5599 – 5607

Abstract

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Nehal Farouk,1 Walaa Mohamed Omar Ashry,2 Hanan A EL-Hagrasy,3 Eman F Mohamed,4 Heba H Eltrawy,5 Asmaa M El-Nasser,6 Walaa Shipl,7 Shahinaz El Attar,7 Lobna Kh Sakr,8 Maisa A Abdel Wahab,1 Eman M Abdelsalam,4 Fawzia A Sharaf,3 Inass Hassan Ahmad9 1Vascular Surgery Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt; 2Microbiology and Immunology Department, Damietta Faculty of Medicine (Girls), Al-Azhar University, Damietta, Egypt; 3Clinical Pathology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt; 4Internal Medicine Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt; 5Chest Diseases Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt; 6Medical Microbiology and Immunology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt; 7Medical Biochemistry and Molecular Biology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt; 8Radio-Diagnosis Department, faculty of medicine for girls, Al-Azhar University, Cairo, Egypt; 9Endocrinology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, EgyptCorrespondence: Heba H Eltrawy, Chest Diseases Department, Faculty of medicine for girls, Al-Azhar University, Cairo, Egypt, Tel +20 1006381297, Email [email protected] and Aim: Deep venous thrombosis (DVT) of the lower extremities is common in Covid-19 patients. Interleukin (IL)-6 and P-selectin were found to be elevated in Covid-19 patients. The current study aimed to evaluate P-selectin and IL6 in Covid-19 patients with DVT and to explore its relation to clinical and laboratory parameters in those patients.Patients and methods: The present retrospective study included 150 hospitalized COVID-19 patients diagnosed on the basis of a positive result of reverse-transcriptase polymerase chain reaction (RT-PCR) test. Laboratory assessments were included for IL-6 and P selectin assessments via enzyme-linked immunosorbent assay. The primary outcome of the present study was the development of DVT detected by Doppler ultrasound (DU) evaluation of the lower extremities during the admission.Results: The present study included 150 hospitalized Covid-19 patients. DVT was developed in 59 patients (39.3%). DVP patients had significantly higher levels of P selectin [76.0 (63.0– 87.0) versus 63.0 (54.3– 75.0), p < 0.001] and IL-6 [37.0 (27.0– 49.0) versus 18.5 (13.5– 31.5), p < 0.001]. ROC curve analysis revealed good performance of P selectin [AUC (95% CI): 0.72 (0.64– 0.81)] and IL-6 [AUC (95% CI): 0.79 (0.71– 0.86)] in identification of DVT. Logistic regression analysis identified the presence of severe disease [OR (95% CI): 9.016 (3.61– 22.49), p < 0.001], elevated P selectin [OR (95% CI): 1.032 (1.005– 1.059), p = 0.018] and elevated IL-6 [OR (95% CI): 1.062 (1.033– 1.091), p < 0.001] as significant predictors of DVT development in multivariate analysis.Conclusion: The present study identified a probable role of elevated P-selectin and IL-6 levels in the DVT development in hospitalized Covid-19 patients.Keywords: Covid-19, deep venous thrombosis, interleukin 6

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