Nature Communications (Jun 2017)

Reproductive fitness and genetic risk of psychiatric disorders in the general population

  • Niamh Mullins,
  • Andrés Ingason,
  • Heather Porter,
  • Jack Euesden,
  • Alexandra Gillett,
  • Sigurgeir Ólafsson,
  • Daniel F. Gudbjartsson,
  • Cathryn M. Lewis,
  • Engilbert Sigurdsson,
  • Evald Saemundsen,
  • Ólafur Ó Gudmundsson,
  • Michael L. Frigge,
  • Augustine Kong,
  • Agnar Helgason,
  • G. Bragi Walters,
  • Omar Gustafsson,
  • Hreinn Stefansson,
  • Kari Stefansson

DOI
https://doi.org/10.1038/ncomms15833
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 6

Abstract

Read online

Why genetic variants that confer risk for psychiatric disorders persist in the genome is an evolutionary conundrum. Here, Mullinset al. report association of polygenic risk for autism with having fewer children and polygenic risk for ADHD with higher reproductive fitness.