Nature Communications (Oct 2022)
Whole genome sequence analysis of blood lipid levels in >66,000 individuals
- Margaret Sunitha Selvaraj,
- Xihao Li,
- Zilin Li,
- Akhil Pampana,
- David Y. Zhang,
- Joseph Park,
- Stella Aslibekyan,
- Joshua C. Bis,
- Jennifer A. Brody,
- Brian E. Cade,
- Lee-Ming Chuang,
- Ren-Hua Chung,
- Joanne E. Curran,
- Lisa de las Fuentes,
- Paul S. de Vries,
- Ravindranath Duggirala,
- Barry I. Freedman,
- Mariaelisa Graff,
- Xiuqing Guo,
- Nancy Heard-Costa,
- Bertha Hidalgo,
- Chii-Min Hwu,
- Marguerite R. Irvin,
- Tanika N. Kelly,
- Brian G. Kral,
- Leslie Lange,
- Xiaohui Li,
- Martin Lisa,
- Steven A. Lubitz,
- Ani W. Manichaikul,
- Preuss Michael,
- May E. Montasser,
- Alanna C. Morrison,
- Take Naseri,
- Jeffrey R. O’Connell,
- Nicholette D. Palmer,
- Patricia A. Peyser,
- Muagututia S. Reupena,
- Jennifer A. Smith,
- Xiao Sun,
- Kent D. Taylor,
- Russell P. Tracy,
- Michael Y. Tsai,
- Zhe Wang,
- Yuxuan Wang,
- Wei Bao,
- John T. Wilkins,
- Lisa R. Yanek,
- Wei Zhao,
- Donna K. Arnett,
- John Blangero,
- Eric Boerwinkle,
- Donald W. Bowden,
- Yii-Der Ida Chen,
- Adolfo Correa,
- L. Adrienne Cupples,
- Susan K. Dutcher,
- Patrick T. Ellinor,
- Myriam Fornage,
- Stacey Gabriel,
- Soren Germer,
- Richard Gibbs,
- Jiang He,
- Robert C. Kaplan,
- Sharon L. R. Kardia,
- Ryan Kim,
- Charles Kooperberg,
- Ruth J. F. Loos,
- Karine A Viaud-Martinez,
- Rasika A. Mathias,
- Stephen T. McGarvey,
- Braxton D. Mitchell,
- Deborah Nickerson,
- Kari E. North,
- Bruce M. Psaty,
- Susan Redline,
- Alexander P. Reiner,
- Ramachandran S. Vasan,
- Stephen S. Rich,
- Cristen Willer,
- Jerome I. Rotter,
- Daniel J. Rader,
- Xihong Lin,
- NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium,
- Gina M. Peloso,
- Pradeep Natarajan
Affiliations
- Margaret Sunitha Selvaraj
- Cardiovascular Research Center, Massachusetts General Hospital
- Xihao Li
- Department of Biostatistics, Harvard T.H. Chan School of Public Health
- Zilin Li
- Department of Biostatistics, Harvard T.H. Chan School of Public Health
- Akhil Pampana
- Program in Medical and Population Genetics, Broad Institute of Harvard and MIT
- David Y. Zhang
- Department of Genetics, Perelman School of Medicine, University of Pennsylvania
- Joseph Park
- Department of Genetics, Perelman School of Medicine, University of Pennsylvania
- Stella Aslibekyan
- Department of Epidemiology, University of Alabama at Birmingham School of Public Health
- Joshua C. Bis
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Jennifer A. Brody
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Brian E. Cade
- Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Lee-Ming Chuang
- Department of Internal Medicine, National Taiwan University Hospital
- Ren-Hua Chung
- Institute of Population Health Sciences, National Health Research Institutes
- Joanne E. Curran
- Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine
- Lisa de las Fuentes
- Department of Medicine, Cardiovascular Division, Washington University School of Medicine
- Paul S. de Vries
- Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Ravindranath Duggirala
- Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine
- Barry I. Freedman
- Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine
- Mariaelisa Graff
- Department of Epidemiology, UNC Chapel Hill
- Xiuqing Guo
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Nancy Heard-Costa
- Department of Neurology, Boston university School of Medicine
- Bertha Hidalgo
- Department of Epidemiology, University of Alabama at Birmingham School of Public Health
- Chii-Min Hwu
- Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital
- Marguerite R. Irvin
- Department of Epidemiology, University of Alabama at Birmingham School of Public Health
- Tanika N. Kelly
- Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine
- Brian G. Kral
- Department of Medicine, Johns Hopkins University School of Medicine
- Leslie Lange
- Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus
- Xiaohui Li
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Martin Lisa
- Department of Medicine, George Washington University
- Steven A. Lubitz
- Cardiovascular Research Center, Massachusetts General Hospital
- Ani W. Manichaikul
- Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia
- Preuss Michael
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- May E. Montasser
- Department of Medicine, University of Maryland School of Medicine
- Alanna C. Morrison
- Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Take Naseri
- Ministry of Health, Government of Samoa
- Jeffrey R. O’Connell
- Department of Medicine, University of Maryland School of Medicine
- Nicholette D. Palmer
- Department of Biochemistry, Wake Forest School of Medicine
- Patricia A. Peyser
- Department of Epidemiology, University of Michigan
- Muagututia S. Reupena
- Lutia i Puava ae Mapu i Fagalele
- Jennifer A. Smith
- Department of Epidemiology, University of Michigan
- Xiao Sun
- Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine
- Kent D. Taylor
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Russell P. Tracy
- Departments of Pathology & Laboratory Medicine and Biochemistry, Larner College of Medicine at the University of Vermont
- Michael Y. Tsai
- Department of Laboratory Medicine and Pathology, University of Minneosta
- Zhe Wang
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Yuxuan Wang
- Department of Biostatistics, Boston University School of Public Health
- Wei Bao
- Institute of Public Health, Division of Life Sciences and Medicine, University of Science and Technology of China
- John T. Wilkins
- Department of Medicine (Cardiology) and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
- Lisa R. Yanek
- Department of Medicine, Johns Hopkins University School of Medicine
- Wei Zhao
- Department of Epidemiology, University of Michigan
- Donna K. Arnett
- Dean’s Office, University of Kentucky College of Public Health
- John Blangero
- Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine
- Eric Boerwinkle
- Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Donald W. Bowden
- Department of Biochemistry, Wake Forest School of Medicine
- Yii-Der Ida Chen
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Adolfo Correa
- Department of Population Health Science, University of Mississippi Medical Center
- L. Adrienne Cupples
- Department of Biostatistics, Boston University School of Public Health
- Susan K. Dutcher
- The McDonnell Genome Institute, Washington University School of Medicine
- Patrick T. Ellinor
- Cardiovascular Research Center, Massachusetts General Hospital
- Myriam Fornage
- Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston
- Stacey Gabriel
- Broad Institute
- Soren Germer
- New York Genome Center
- Richard Gibbs
- Baylor College of Medicine Human Genome Sequencing Center
- Jiang He
- Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine
- Robert C. Kaplan
- Department of Epidemiology and Population Health, Albert Einstein College of Medicine
- Sharon L. R. Kardia
- Department of Epidemiology, University of Michigan
- Ryan Kim
- Psomagen, Inc. (formerly Macrogen USA)
- Charles Kooperberg
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Ruth J. F. Loos
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Karine A Viaud-Martinez
- Illumina Laboratory Services, Illumina. Inc
- Rasika A. Mathias
- Department of Medicine, Johns Hopkins University School of Medicine
- Stephen T. McGarvey
- Department of Epidemiology, International Health Institute, Brown University
- Braxton D. Mitchell
- Department of Medicine, University of Maryland School of Medicine
- Deborah Nickerson
- University of Washington, Department of Genome Sciences
- Kari E. North
- Department of Epidemiology, UNC Chapel Hill
- Bruce M. Psaty
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Susan Redline
- Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Alexander P. Reiner
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Ramachandran S. Vasan
- Sections of Preventive medicine and Epidemiology, Cardiovascular medicine, Department of Medicine, Boston University School of Medicine
- Stephen S. Rich
- Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia
- Cristen Willer
- University of Michigan, Internal Medicine
- Jerome I. Rotter
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Daniel J. Rader
- Department of Genetics, Perelman School of Medicine, University of Pennsylvania
- Xihong Lin
- Program in Medical and Population Genetics, Broad Institute of Harvard and MIT
- NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
- Gina M. Peloso
- Department of Biostatistics, Boston University School of Public Health
- Pradeep Natarajan
- Cardiovascular Research Center, Massachusetts General Hospital
- DOI
- https://doi.org/10.1038/s41467-022-33510-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Although the common genetic variants contributing to blood lipid levels have been studied, the contribution of rare variants is less understood. Here, the authors perform a rare coding and noncoding variant association study of blood lipid levels using whole genome sequencing data.
