Nature Communications (Sep 2019)
Molecular basis for metabolite channeling in a ring opening enzyme of the phenylacetate degradation pathway
Abstract
The bacterial enzyme PaaZ is involved in the breakdown of environmental pollutants via the aerobic-anaerobic hybrid pathway but its substrate transfer mechanism is not fully understood. Here, the authors present cryoEM structures of free and ligand-bound PaaZ that suggest a mechanism for internal substrate channeling.