Nature Communications (Sep 2019)

Molecular basis for metabolite channeling in a ring opening enzyme of the phenylacetate degradation pathway

  • Nitish Sathyanarayanan,
  • Giuseppe Cannone,
  • Lokesh Gakhar,
  • Nainesh Katagihallimath,
  • Ramanathan Sowdhamini,
  • Subramanian Ramaswamy,
  • Kutti R. Vinothkumar

DOI
https://doi.org/10.1038/s41467-019-11931-1
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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The bacterial enzyme PaaZ is involved in the breakdown of environmental pollutants via the aerobic-anaerobic hybrid pathway but its substrate transfer mechanism is not fully understood. Here, the authors present cryoEM structures of free and ligand-bound PaaZ that suggest a mechanism for internal substrate channeling.