Frontiers in Neurology (Jun 2022)

Clinical, Radiological and Pathological Characteristics Between Cerebral Small Vessel Disease and Multiple Sclerosis: A Review

  • Bijia Wang,
  • Xuegang Li,
  • Haoyi Li,
  • Li Xiao,
  • Zhenhua Zhou,
  • Kangning Chen,
  • Li Gui,
  • Xianhua Hou,
  • Rong Fan,
  • Kang Chen,
  • Wenjing Wu,
  • Haitao Li,
  • Xiaofei Hu

DOI
https://doi.org/10.3389/fneur.2022.841521
Journal volume & issue
Vol. 13

Abstract

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Cerebral small vessel disease (CSVD) and multiple sclerosis (MS) are a group of diseases associated with small vessel lesions, the former often resulting from the vascular lesion itself, while the latter originating from demyelinating which can damage the cerebral small veins. Clinically, CSVD and MS do not have specific signs and symptoms, and it is often difficult to distinguish between the two from the aspects of the pathology and imaging. Therefore, failure to correctly identify and diagnose the two diseases will delay early intervention, which in turn will affect the long-term functional activity for patients and even increase their burden of life. This review has summarized recent studies regarding their similarities and difference of the clinical manifestations, pathological features and imaging changes in CSVD and MS, which could provide a reliable basis for the diagnosis and differentiation of the two diseases in the future.

Keywords