Enhancer and super-enhancer dynamics in repair after ischemic acute kidney injury

Julia Wilflingseder; Michaela Willi; Hye Kyung Lee; Hannes Olauson; Jakub Jankowski; Takaharu Ichimura; Reinhold Erben; M. Todd Valerius; Lothar Hennighausen; Joseph V. Bonventre

doi:10.1038/s41467-020-17205-5

Nature Communications (Jul 2020)

Enhancer and super-enhancer dynamics in repair after ischemic acute kidney injury

Julia Wilflingseder,
Michaela Willi,
Hye Kyung Lee,
Hannes Olauson,
Jakub Jankowski,
Takaharu Ichimura,
Reinhold Erben,
M. Todd Valerius,
Lothar Hennighausen,
Joseph V. Bonventre

Affiliations

Julia Wilflingseder: Brigham and Women’s Hospital, Renal Division, Harvard Medical School
Michaela Willi: Laboratory of Genetics and Physiology, NIDDK, NIH
Hye Kyung Lee: Laboratory of Genetics and Physiology, NIDDK, NIH
Hannes Olauson: Brigham and Women’s Hospital, Renal Division, Harvard Medical School
Jakub Jankowski: Laboratory of Genetics and Physiology, NIDDK, NIH
Takaharu Ichimura: Brigham and Women’s Hospital, Renal Division, Harvard Medical School
Reinhold Erben: Department of Physiology and Pathophysiology, University of Veterinary Medicine
M. Todd Valerius: Brigham and Women’s Hospital, Renal Division, Harvard Medical School
Lothar Hennighausen: Laboratory of Genetics and Physiology, NIDDK, NIH
Joseph V. Bonventre: Brigham and Women’s Hospital, Renal Division, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-020-17205-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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Acute kidney injury is a major health problem amongst hospitalized patients. Here the authors provide a comprehensive characterization of enhancer and super-enhancer elements, and the transcription factor motifs associated with these elements in response to kidney injury in vivo; providing insight into the regulation of kidney repair.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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